Description
Product Characteristics:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Kr_ppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF239, also known as Zinc finger protein MOK-2 or HOK-2, is a 458 amino acid protein belonging to the Kr_ppel C2H2-type zinc-finger protein family. Localized to the nucleus, ZNF239 contains nine C2H2-type zinc finger domains. Due to the presence of these domains, ZNF239 may be involved in transcriptional regulation. ZNF239 is present at high levels in brain, breast and testis, and has no expression in liver or placenta.
Subcellular location: Nucleus
Synonyms: HOK 2, Kruppel zinc finger protein 2, MOK 2, MOK2, OTTHUMP00000019484, OTTMUSP00000024957, zfp 239, Zinc finger protein C2H2 homologous to mouse MOK 2, zinc finger protein 239, Zinc finger protein HOK 2, Zinc finger protein HOK-2, zinc finger protein MOK 2, Zinc finger protein MOK-2, ZN239_HUMAN, Znf239.
Target Information: MOK2 proteins are DNA- and RNA-binding proteins that are mainly associated with nuclear RNP components, including the nucleoli and extranucleolar structures (Arranz et al., 1997 [PubMed 9121460]).[supplied by OMIM, Mar 2008]